Home Department: Human Biology
Mentor: Joseph Wu, Medicine (Cardiovascular Medicine) and Radiology
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a promising class of diabetes medications that have been shown to improve the vascular outcomes of patients with type 2 diabetes mellitus. The mechanisms by which these medications improve vascular endpoints are not known. Emma’s project will use patient-specific stem cell-derived endothelial cells to investigate the potential of these inhibitors in reducing endothelial inflammation, a possible mechanism for why diabetic patients treated with these medications have improved vascular outcomes.