Home Department: undeclared
Mentor: Jennifer Cochran, Bioengineering
Prodrugs—drugs that are inactive when given to patients but become activated at specific sites within the body—offer a promising solution to the problem of treatment-induced autoimmune side effects associated with cancer immunotherapy. To test cancer immunotherapy prodrugs, it is important to design a mouse model that accurately represents how the drugs will perform in humans. Jessica’s project focuses on creating a mouse cancer cell line that expresses the human proteins involved in prodrug activation, thereby allowing the Cochran lab to test cancer immunotherapy prodrugs for both efficacy and toxicity in vivo.