Home Department: Chemistry
Mentor: Gerlinde Wernig, Pathology
Desmoid-type fibromatosis is a devastating low-grade soft tissue malignancy which infiltrates the surrounding connective tissue. Tyler will be analyzing β-catenin, one of the known molecular drivers of desmoid-type fibromatosis, and its relation to c-Jun, a protein which plays a crucial role in tumor development, using a c-Jun induced mouse model. This work will determine whether c-Jun and its mouse model can be used as a new and valuable tool for research as well as for patients and physicians.